CASP3 and breast cancer: He et al. and colleagues utilized a PLGA nanoparticulate platform to encapsulate saturated FA palmitic acid (PA), with DOX or alone, to investigate the potential of PA as a monotherapy or combination therapy for BC and suggest that the PLGA-PA-NPs were as effective in reducing primary tumor growth and metastasis reduced the expression of genes associated with multi-drug resistance and inhibition of apoptosis, and induced apoptosis via a caspase-3-independent pathway in breast cancer cells.