BRCA1 and breast cancer: Different types of biomarkers used for the prognosis of BC comprise BRCA1/2 gene mutations, serum biomarkers like carcinoembryonic antigen (CEA) or cancer antigen 15-3 (CA 15-3), circulating tumor-derived DNA, circulating tumor cells, and a multi-analyte profile of Oncotype DX or uPA/PAI-1, etc. [28].