The recent development of niosome nanoparticles as a delivery system for Cyclophosphamide (CYC) and Sodium Oxamate enhances cytotoxicity, induces apoptosis, elevates NRF2 protein levels, and increases expression of caspase-3 and Bax, confirming the activation of apoptotic pathways, leading to effective strategies for managing breast cancer [143]. The gene discussed is CASP3; the disease is breast carcinoma.