The findings from the CCK8 assay indicated that diminished expression of NLRP5 notably hindered the proliferation ability of HCCLM3 and HEPG2 cells, whereas reduced expression of NLRP4 did not exert any influence on the proliferation ability of HCC cell lines (Fig. 6D,E). Here, NLRP4 is linked to hepatocellular carcinoma.