STAT3 and triple-negative breast carcinoma: Similarly, electrospun PLA scaffolds, especially with aligned fibers, promote tumor aggressiveness and EMT-related gene expression [262], while PLA nanofiber scaffolds support the growth of triple-negative breast cancer cells and increase signal transducer and activator of transcription 3 (STAT3) activation and CSC markers, making them suitable for short-term 3D culture applications [251].