Analysis of data from The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), Repository for Molecular Brain Neoplasia Data (Rembrandt), and Gene Expression Profiling Interactive Analysis (GEPIA) databases reveals that the expression of CAMK2B is significantly reduced in both low-grade gliomas and glioblastomas compared to normal brain tissue. The gene discussed is CAMK2B; the disease is glioma.