Podophyllotoxin and its derivatives can not only destabilize microtubules to arrest cells in G2/M phase, but also regulate the expression of related proteins, such as suppression of cell cycle proteins B1, CDK1, Cyclin E, and Cdc25C, DPT derivatives can inhibit the arrest of lung cancer cells A549 in the G1 phase, exemplifying that altering the structure may result in a different action effect. This evidence concerns the gene CCNE1 and lung carcinoma.