Studies in colorectal cancer confirmed that OTUD1 cleaves the K48-type and K63-type polyUb chains of IREB2 protein, and stabilized IREB2 protein increases intracellular iron concentration through activation of TFRC, and the accumulation of excess iron leads to the continuous production of ROS, which ultimately induces ferroptosis in cancer cells [30]. This evidence concerns the gene IREB2 and cancer.