YOD1 and familial pancreatic carcinoma: In addition, the expression level of OTUD2 protein in pancreatic cancer tissues was significantly higher than that in normal tissues adjacent to cancer, and the overexpression of OTUD2 not only promotes the proliferation and metastasis of pancreatic cancer cells but also correlates with the immunosuppressive tumor microenvironment, which is an unfavorable prognostic indicator for overall survival and recurrence-free survival [43].