HIF1A and hepatocellular carcinoma: In turn, upregulated OTUD6B was able to prevent the degradation of pVHL protein by maintaining the stability of the pVHL-CBC ligase complex, which in turn inhibited the activation of the HIF-1α signaling axis and ultimately inhibited the migration and metastasis of HCC cells, suggesting the existence of negative feedback regulation between HIF-1α/OTUD6B/pVHL [95,96].