In breast cancer, OTUD6A was found to accumulate in large numbers at DNA damage sites and increase the stability of DNA topoisomerase II-binding protein 1(TopBP1) by cleaving the K48-type polyUb chain, thereby initiating the DNA damage response (DDR) pathway, leading to tumor cell proliferation, migration, and invasion [86]. The gene discussed is OTUD6A; the disease is breast cancer.