In summary, OTUD1 relies on its deubiquitination to regulate the expression of a variety of downstream proteins, including P53, SMAD7, YAP, KLF4, FHL1, AIF, DCAF10, IREB2, PTEN, Bim, thus regulating tumor cell signaling and exerting significant tumor suppressor effects. Here, OTUD1 is linked to neoplasm.