The deubiquitinating enzyme activity of OTUD3 has been reported to be tightly regulated by acetylation modifications, and acetylated OTUD3 is involved in physiological or pathological disease processes by removing the Ub chain of a variety of proteins, including cancers, antiviral responses, neurological disorders, embryonic development, and metabolic diseases [52]. This evidence concerns the gene OTUD3 and Other metabolic disease.