YAP1 and cancer: We suggest that the relationship between OTUD2 and HCC can be jointly explored from the combined perspectives of cell lines, mouse cancer models, and clinical patients, such as complementing the effects of OTUD2 overexpression or knockdown on the behavior of HCC cells and the size of the lumps in mouse HCC models, as well as exploring the impact of OTUD2 on the YAP/β-catenin pathway.