Compared with normal samples, the expression level of OTUD1 was significantly downregulated in non-small cell lung cancer (NSCLC) tissues and cell lines, whereas OTUD1 overexpression significantly inhibited the proliferation, migration, and invasion of NSCLC cells, as well as improved OS in NSCLC patients, suggesting that OTUD1 is an oncogene in NSCLC [33–36]. Here, OTUD1 is linked to non-small cell lung carcinoma.