In summary, OTUD1 relies on its deubiquitination to regulate the expression of a variety of downstream proteins, including P53, SMAD7, YAP, KLF4, FHL1, AIF, DCAF10, IREB2, PTEN, Bim, thus regulating tumor cell signaling and exerting significant tumor suppressor effects. The gene discussed is PTEN; the disease is neoplasm.