In 2014, Carneiro et al. identified and characterized OTUD1 by single-chain variable fragment antibody-antigen assay and named it DUBA7, which is differentially expressed in thyroid cancer and can be used as a biomarker for early thyroid cancer, but the authors did not study the effect of OTUD1 on thyroid cancer progression in-depth [13]. This evidence concerns the gene OTUD1 and thyroid gland carcinoma.