Promyelocytic leukemia (PML) protein acts as a tumor suppressor by regulating P53 transcription, and they demonstrated that OTUD5 acts as a tumor suppressor by cleaving the K63-type polyUb chain inhibits TRIM25 activity, thereby suppressing TRIM25 enrichment on the PML promoter, which in turn promotes PML transcription and inhibits HCC and NSCLC progression [71]. The gene discussed is TRIM25; the disease is hepatocellular carcinoma.