It has been reported that the expression level of OTUD6A in colorectal cancer tissues is significantly higher than that in normal tissues, and OTUD6A can increase the stability and promote the expression of Drp1 protein through ubiquitination, which promotes the onset of Drp1-mediated mitochondrial fission, and enhances the proliferation and colony formation of cancer cells [83]. This evidence concerns the gene OTUD6A and colorectal cancer.