The oncolytic virus Ad5/3-d24-E2F-hTNFa-IRES-hIL2 (TILT-123 or OAd.TNFa-IL2) remodels the tumor microenvironment by inducing the release of danger-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs), activating Absent in Melanoma 2 inflammasomes, and fostering an immune-stimulatory, anti-tumor milieu. This evidence concerns the gene TNF and neoplasm.