In gastric cancer (GC) liver metastasis models, scRNA-seq revealed significant enrichment of immunosuppressive populations including cancer-associated fibroblasts (CAFs), MDSC-like macrophages, TAM-like macrophages, and naïve T cells, alongside marked reductions in conventional dendritic cells (cDCs) and effector CD8+ T cells [34]. Here, CD8A is linked to gastric cancer.