The 2021 5th edition WHO classification further expanded the category of embryonal tumors by including two newly defined genetically characterized tumors: central nervous system neuroblastoma (driven by FOXR2) and CNS tumors with internal tandem duplications of BCOR, alongside the atypical teratoid/rhabdoid tumor (AT/RT) and embryonal tumor with multilayered rosettes (ETMR), already described in the previous classification. This evidence concerns the gene BCOR and embryonal neoplasm.