The 2021 5th edition WHO classification sees the category of Embryonal Tumors growing yet again, with inclusion of 3 new genetically defined tumor types: (i) cribriform neuroepithelial tumor (CRINET), (ii) CNS neuroblastoma, FOXR2-activated, and (iii) CNS tumour with BCOR internal tandem duplication [7]. This evidence concerns the gene FOXR2 and central nervous system neoplasm.