CXCL8 and neoplasm: On the one hand, senescence rewires cytoskeletal, adhesion, and motility programs, intrinsically reducing migratory and invasive capacities; on the other, SASP factors (e.g., IL-6/IL-8 and chemokines) enhance immune surveillance and phagocytic clearance, creating—when appropriately timed and sufficiently deep—a tumor-suppressive ecosystem that scales single-cell arrest into population-level constraints on dissemination (Chibaya et al., 2022).