Tsvetkov et al. (Tsvetkov et al., 2022b) identified 10 CRGs, of which 7 are positively regulated genes, specifically LIAS, FDX1, DLD, LIPT1, PDHB, DLAT, and PDHA1; and three are negatively regulated genes, specifically GLS, MTF1, and CDKN2A.The introduction of the concept of cuproptosis rapidly attracted the attention of medical researchers, and a number of recent studies have found that copper plays an integral role in tumor immunity and antitumor therapy plays an indispensable role (Santini et al., 2014). The gene discussed is PDHA1; the disease is neoplasm.