LRRK2 and Parkinson disease: pT73-Rab10 elevated in PBMCs from iPD patients and affected G2019S-LRRK2 carriers (not in A53T-α-Syn PD). pS1292-LRRK2 often undetectable in iPD urinary EVs. Unchanged pT73-Rab10 in urinary EVs from iPD (cross-sectional).