3. At least 5 of 7 of the below features  a. Fever ≥ 38.5°C  b. Splenomegaly (≥ 2 cm below the costal margin)  c. Cytopenias affecting at least 2 lineages (Hgb <9 g/dL*, platelets <100,000/μL, ANC <1000/μL  d. Hypertriglyceridemia (fasting ≥ 3mmol/L) and/or hypofibrinogenemia (≤ 1.5 g/L)  e. Hemophagocytosis  f. Ferritin ≥500 μg/L  g. Soluble IL2R (a.k.a. CD25) ≥2400 U/mL. The gene discussed is IL2RA; the disease is hypertriglyceridemia.