While pathway-level dysregulation overlapped partially with the previous findings (e.g.,disturbances in amino acid metabolism), there was no direct overlap in the specific metabolitesidentified, potentially reflecting biological differences between OIPN onset and progression stages.Notably, the current study highlighted abnormalities in pathways including ABC transporters andcentral carbon metabolism in cancer, whereas the prior study emphasized arginine biosynthesis, beta-alanine metabolism, and linoleic acid metabolism. The gene discussed is ABCG2; the disease is cancer.