In addition, our data further demonstrate that ARID1A depletion enhances the sensitivity of SCLC cell lines to the BET inhibitor JQ1, and the compound BRD-K98645985 exerts antitumor effects against SCLC through targeted inhibition of ARID1A while also synergizing with JQ1 to suppress SCLC growth. This evidence concerns the gene DNER and small cell lung carcinoma.