Similar increases in circuit excitation were also observed with the tau species present in human CSF (Brown et al., 2023) and it has been reported that epileptic activity occurs in a mouse transgenic line over-expressing human mutant tau, a model of frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17, García-Cabrero et al., 2013). Here, MAPT is linked to frontotemporal dementia.