Recently, a link has also been established between insulin resistance and the expression of neutrophil elastase (NE) or cathepsin S (Blaise et al., 2013; Lafarge et al., 2010; Lafarge et al., 2014; Mansuy-Aubert et al., 2013); this condition aggravates the fragmentation of elastin. The gene discussed is ELN; the disease is Insulin resistance.