Comparing the DKD and NDKD groups in the training set, the following indicators showed statistical differences: In the DKD group, the proportion of males, height, diabetes duration, proportion of DR, SBP (Systolic Blood Pressure), PP (Pulse Pressure), Scr, UREA, UA, ALB, Glu, HbA1c, and U_κ were higher; age, eGFR, TC, LDL-C, 24hUTP, RBC, HGB, and HCT levels were lower. This evidence concerns the gene CYGB and diabetes mellitus.