CTSL and neoplasm: This pathway includes major immune-regulatory molecules such as cathepsin L/S/B, vesicle-associated membrane protein 8 (VAMP8), Rab guanosine triphosphatases (GTPases), Toll-like receptor 2/4/7 (TLR2/4/7), Fc gamma receptors, and heat-shock protein 90 (HSP90) family chaperones, many of which participate in vesicle fusion, lysosomal trafficking, and impaired antigen presentation under tumor progression (Fig. 6B; Supplementary Table 2, Rank #1).