A Kyoto Encyclopedia of Genes and Genome (KEGG) analysis revealed that gene co-expressed with ORMDL2 were enriched in pathways such as oxidative phosphorylation (OXPHOS), lysine degradation, non-alcoholic fatty liver disease, and neurodegenerative disease modules including Parkinson's and Huntington's disease, which were associated with mitochondrial dysfunction in GBM. Here, ORMDL2 is linked to juvenile Huntington disease.