In response to allergenic challenges, FoxO1 overexpression in macrophages has been associated with lung inflammation in asthma 44 In the same way, proteins described in the pathway of FOXO, such as transforming growth factor-beta receptor type 1 (TGFβ-R1) and receptor type 2 (TGFβ-R2) are associated with the airway remodelation process 45. This evidence concerns the gene TGFBR1 and asthma.