CHAF1B and lung adenocarcinoma: For instance, Mu et al. Demonstrated that CHAF1B overexpression confers radioresistance in nasopharyngeal carcinoma 20, while Lian et al. reported that the expression of CHAF1B was elevated in cisplatin-resistant lung adenocarcinoma cells compared to control cells, and knockdown of CHAF1B significantly increased sensitivity to cisplatin 19.