Prophylactic salpingo-oophorectomy is recommended after childbearing is complete or by age 35–40 for BRCA1 mutation carriers and 40–45 for BRCA2 mutation carriers, dramatically reducing ovarian and breast cancer risk in perimenopausal women. Salpingectomy with delayed oophorectomy can be considered in younger patients. This evidence concerns the gene BRCA1 and breast carcinoma.