ABL1 and acute lymphoblastic leukemia: Although research indicates that ABL fusion and activation of the JAK-STAT signaling pathway are commonly present in this subtype (Roberts et al., 2017a; Roberts et al., 2012), some cases of Ph-like ALL do not have typical identifiable genetic abnormalities; this, to some extent, limits diagnostic accuracy based on traditional cell morphology and immunophenotypes (Tran and Tasian, 2022; Schwab and Harrison, 2018; Anagnostou et al., 2020; Tasian et al., 2017).