In Ph-like ALL cases, some studies have shown that IK6 deletion has an independent prognostic impact, tripling the risk of treatment failure (Hu et al., 2023; Stanulla et al., 2018), while others suggest that IKZF1 deletion is not significantly correlated with disease relapse or long-term survival (Cho et al., 2021). Here, IKZF1 is linked to acute lymphoblastic leukemia.