Among the 12 genes (APCDD1L, CD70, FBXO39, GALNT5, HMGA2, HOXA3, HOXC6, HOXC9, HOXD11, SHOX2, MEOX2, OTP) within normal detection thresholds, differential expression was observed between tumor and adjacent tissues (Supplementary Figure S3B). The gene discussed is FBXO39; the disease is neoplasm.