SMARCA2/4 belong to the SWI/SNF complex, and in SMARCA4‐deficient backgrounds, SMARCA2 becomes a critical “synthetic lethal” dependency target, with related degraders such as ACBI1 and AU‐15330 demonstrating promising targeting and therapeutic potential in SMARCA4‐deficient and NSCLC models [237]. This evidence concerns the gene SMARCA4 and non-small cell lung carcinoma.