In a recent study by Huang et al., the upregulation of Zyxin, a focal adhesion protein, was identified as a driver of skin fibrosis through integrin‐mediated coactivation of the FAK/PI3K/Akt and TGF‐β pathways, and genetic or pharmacologic inhibition of Zyxin attenuated fibrosis in both human keloid explants and murine models [112]. This evidence concerns the gene TGFB1 and keloid.