In addition to the TGF‐β, integrin–FAK, and YAP/TAZ signaling pathways, several other mechanotransduction cascades—including the PI3K/Akt, Rho GTPase, and ion channel pathways—respond to mechanical stimuli and contribute to fibroblast activation, ECM accumulation, and sustained fibrosis in HTS and keloids. The gene discussed is PTK2; the disease is keloid.