TNBC cells exhibit hyperactivation of several signaling pathways, including the PI3K/Akt/mTOR, Wnt/β‐catenin, JAK2/STAT3, Ras/Raf/MEK/ERK, Notch, and Hh pathways, all of which contribute to tumor initiation and progression [543]. This evidence concerns the gene STAT3 and neoplasm.