By collecting pre- and post-NAT ultrasound imaging data from HER2-positive breast cancer and TNBC patients, we systematically analyzed the changes in the following parameters: maximum tumor diameter, tumor remission rate, peritumoral echogenicity, posterior echogenicity, tumor CDFI signal, lymph node remission rate, lymph node CDFI signal and hyperechoic medulla visible. Here, ERBB2 is linked to breast cancer.