BCL2 and posterior cortical atrophy: To explore the mechanisms by which CCNB2 affects the biological behavior of PCa, we performed CCNB2 gene knockdown in PC3 and DU145, and then analyzed the impact of this knockdown on the apoptotic pathway (Caspase-3, Bcl-2, Bax) and the disulfidptosis pathway (SLC7A11) using western blot (Figure 8K, L).