TNF and cancer: According to the results of the GSEA of cancer hallmarks, the high FAMS group was enriched in epithelial-to-mesenchymal transition (EMT), hypoxia, and TNFA signaling via NF-κB (Figure 5C-E), and the low FAMS group was enriched in the G2M checkpoint, MYC targets V1, and DNA repair (Figure 5F-H).