For instance, HSD17B8 has colocalization with lymphoid leukemia and chronic lymphocytic leukemia; RPN1 has colocalization with myeloproliferative diseases (excluding CML) and polycythaemia vera; and PARP1 has colocalization with myeloproliferative diseases (excluding CML) and polycythaemia vera. The gene discussed is RPN1; the disease is acquired polycythemia vera.