RYR2 and hydrops fetalis: ,, Along this, SERCA2a and RyR2 aresensitive to oxidative modifications, especially on cysteine residues,leading to a reduction of SERCA2a and increase of RyR2 activities., Thus, a higher level of oxidative stress in HF causes impaired Ca2+ replenishment in the SER of cardiomyocytes and results indelayed diastolic relaxation.−,