LCN2 and alkaline phosphatase measurement: Human Ptx3, Lcn2, Cp, and total copper creatine-adjustedindices (Ptx3/Cr, Lcn2/Cr, Cp/Cr, and Cu/Cr) levels were significantlyelevated in urine samples of AC, cUTI, and AP patients compared toCtrls, and they showed the same increasing concentration trend fromAC to AP (Figure A–C).Median Lcn2/Cr indices with interquartile range (IQR) were 0.1 (0.1–0.1),0.5 (0.3–0.7), 0.7 (0.4–10.8), and 1.6 (0.5–2.7)μg/mmol in Ctrl, AC, cUTI, and AP patient groups, respectively(Table ).