In the second step, ambiguous patientcases with an Lcn2/Cr index of 0.45 μg/mmol (DET) were sortedby elevated urinary Cu/Cr index., Patients withCu/Cr ≥ 4.8 μg/mmol (median for AP + cUTI groups) wereclassified as belonging to the AP and cUTI group, while patients withCu/Cr < 4.8 μg/mmol were classified as the AC group. The gene discussed is LCN2; the disease is alkaline phosphatase measurement.