These include lower patient age, large magnetic resonance imaging (MRI) diffusion-weighted imaging core volume, lower Alberta stroke program early computed tomography (CT) score, proximal artery occlusion including MCA and internal carotid artery (ICA) occlusion, lower collateral score, longer times from onset to groin puncture, unsuccessful reperfusion defined as an expanded treatment in cerebral infarction (eTICI) score of 0–2a, elevated S100B as a serum biomarker, and a severe deficit assessed by the National Institutes of Health Stroke Scale (NIHSS) at initial presentation.7, , , , –12. Here, S100B is linked to Stroke.