SNCA and Parkinson disease: For example, one proposed mechanism involves irisin, a myokine released during physical activity, which has been reported to suppress alpha-synuclein pathology and exert neuroprotective effects in Parkinson’s disease animal models.30 Both Cancer and Parkinson’s disease may lead to decreased activity and performance status, which may result in a loss of beneficial benefits from exercise and may affect the course of the disease.