BAD and neoplasm: This results in a reduction of the Bcl-2 associated death promoter (Bad), a decrease in the expression of the Bad-regulated mitochondrial protein Bcl-xl, and an increased release of mouse cytochrome C. The release of cytochrome C from the mitochondrial membrane space into the cytosol is a significant event in caspase-dependent apoptosis in tumor cells (Lu et al., 2016).