AKT1 and pancreatic ductal adenocarcinoma: In pancreatic ductal adenocarcinoma (PDAC) models, Uro A downregulates the PI3K/AKT/mTOR pathway by inhibiting phosphorylation of Akt and p70S6K in human (MiaPaCa2, BxPC3, PANC1) and murine (K8484) PDAC cells, reducing proliferation while enhancing apoptosis.