Ppp1r3c and Ppp1r3b can be widely expressed in liver, muscle, and cardiac muscle and can target glycogen granules by dephosphorylating and activating glycogen synthase Ppp1r3c heterozygous deletion in mice resulting in reduced tissue glycogen levels with progressive glucose intolerance, hyperinsulinemia and insulin resistance with age (50). Here, PPP1R3C is linked to hyperinsulinism.