The discovery of lactylation modification provides a new perspective for PD treatment: as a triple regulatory node of metabolism, epigenetics, and inflammation, it can explain the co-occurrence of energy metabolism abnormalities and neuroinflammation in PD, and lay a theoretical foundation for developing multidimensional intervention strategies targeting both the NLRP3 inflammasome and mitophagy. Here, NLRP3 is linked to Parkinson disease.