Eleutheroside B enhances the interaction between p53 apoptosis-stimulating protein inhibitor (iASPP) and Keap1, stabilizes Nrf2 levels in the brains of APP/PS1 mice, inhibits p53 DNA-binding activity, reduces oxidative stress in the brain, decreases Aβ accumulation and neuronal apoptosis, improves hippocampal synaptic plasticity, and thereby alleviates cognitive deficits in APP/PS1 mice (Ding et al., 2022). Here, TP53 is linked to Cognitive impairment.