CDK1 and neoplasm: KEGG/GO enrichment analysis showed that various pathways can potentially be influenced by the upregulation of CDK1 gene, e.g., mitochondrial ATP synthesis coupled electron transport, G2/M transition of mitosis, protein serine/threonine kinase activity, etc. We found that ESR1 is involved in proteoglycan mediated cell signaling pathways and shaping the tumor microenvironment.