Mechanistically, 6 TFs (STAT5A/B, NFKB1, EGR1, RELA, and CTCF) emerged as central transcriptional regulators, while the miRNAs exhibited specific target interactions: hsa-miR-204: IL7R and PRF1/SELL; hsa-miR-148b: GZMK and SELL; hsa-miR-618: IL7R and GZMK; hsa-miR-103: CD19 and GZMK; These computational predictions require experimental validation to confirm their biological relevance in NSCLC-BM pathogenesis. Here, PRF1 is linked to non-small cell lung carcinoma.