COL1A1 and cancer: Examples include COL1A1 (a known cancer driver gene) with its 13 isoforms, which are negatively correlated with stemness in the multi-element signature HNSC-308.5.3.N.3.0.0.3.2.3, comprising 46 member elements, and UMOD with its 12 transcripts, also negatively associated with stemness in the multi-element signature KICH-117.5.3.N.2.0.0.2.4.3, which comprises 61 member elements (Figure 6).