The positive correlation between CD274 mutations and TMB in GBM-410.2.1.P.3.35.0.4.4.8, LGG-1442.2.1.P.3.35.0.3.4.8, and PAAD-773.2.1.P.3.42.0.2.4.8 suggests that higher TMB, often associated with better responses to immunotherapy, is linked to the occurrence of CD274 mutations (Supplementary Figure S10, Supplementary Dataset S1X). The gene discussed is CD274; the disease is glioblastoma.