PGR and neoplasm: Decision aids like PREDICT, Nottingham Prognostic Index (NPI) and Adjuvant Online based on IHC4 (ER/PR/HER2/Ki67) or IHC4+C (including clinical/pathological features like age, tumour size, grade and nodal status) parameters define the level of clinical risk for adjuvant chemotherapy without relying on tumour profiling tests.