Decision aids like PREDICT, Nottingham Prognostic Index (NPI) and Adjuvant Online based on IHC4 (ER/PR/HER2/Ki67) or IHC4+C (including clinical/pathological features like age, tumour size, grade and nodal status) parameters define the level of clinical risk for adjuvant chemotherapy without relying on tumour profiling tests. The gene discussed is MKI67; the disease is neoplasm.