Hypoglycaemia rates in patients with type 1 diabetes treated with once‐weekly basal insulins are higher than those observed in patients with type 2 diabetes treated with the same regimen,13, 26 possibly due to differences in glycaemic variability, counterregulatory mechanisms, insulin sensitivity and the degree of endogenous insulin deficiency, all of which may contribute to distinct hypoglycaemia risks and patterns in these populations. The gene discussed is INS; the disease is type 1 diabetes mellitus.