SPP1 and neoplasm: Different subsets of immunosuppressive TAMs (SPP1-C1Qa/b, proliferating, Nos2 glycolytic and OXPHOS TAMs) exhibited high expression of Trem2, Axl, Tim3 and Arg1, known markers of a pro-tumor phenotype, and were proportionally decreased in response to ACTM-838 treatment (except OXPHOS TAMs) [51–53] (Figure 7B, 7C).