Interestingly, our results indicated different airway expression patterns of most SARS‐CoV‐2 entry‐associated proteins in COPD patients as compared to non‐COPD controls, with significantly lower protein expression of HSPA5 (percentage area and mean intensity), ITGB6 (percentage area), as well as NRP1, BSG, and TMPRSS2 (mean intensity). This evidence concerns the gene TMPRSS2 and chronic obstructive pulmonary disease.