Our study demonstrates that, at a protein level, most of the studied SARS‐CoV‐2 entry‐associated proteins showed lower expression in airway epithelium of COPD patients compared to non‐COPD controls, which was significant for HSPA5, NRP1, BSG, TMPRSS2, and ITGB6. The gene discussed is TMPRSS2; the disease is chronic obstructive pulmonary disease.