Among the three DLBCL‐NOS, one case (Case‐21) with IGH::MYC and BCL6 translocation showed mutation in several SHM target genes (MYC, CXCR4, HIST1H1C, HIST1H2BK) and also evidence of SHM in its rearranged IGHV gene (Figure 3A). This evidence concerns the gene BCL6 and diffuse large B-cell lymphoma.