Among the three DLBCL‐NOS, one case (Case‐21) with IGH::MYC and BCL6 translocation showed mutation in several SHM target genes (MYC, CXCR4, HIST1H1C, HIST1H2BK) and also evidence of SHM in its rearranged IGHV gene (Figure 3A). The gene discussed is CXCR4; the disease is diffuse large B-cell lymphoma.