However, aberrant TdT expression may also be seen in DLBCL/HGBCL without MYC and BCL2 translocation [1], and such cases may also bear features of immaturity such as loss of CD20, BCL6, and/or immunoglobulin light chain expression, posing a real challenge in their differential diagnosis from B‐ALL/LBL due to a lack of pathognomonic genetic changes in the former [13]. This evidence concerns the gene MYC and acute lymphoblastic leukemia.