As expected, the mutation load of SHM target genes was significantly higher in DLBCL/HGBCL‐MYC/BCL2 and DLBCL/HGBCL‐NOS than in B‐ALL (p = 2.2E−16 and p = 2.98E−05, respectively) (Figure 3B), with the vast majority (23/25 = 92%) of the DLBCL/HGBCL‐MYC/BCL2 and DLBCL/HGBCL‐NOS harbouring a mutation load above the mean plus two standard deviations of the B‐ALL group. This evidence concerns the gene BCL2 and acute lymphoblastic leukemia.