ESR1 and neoplasm: This mechanism not only stabilizes ERα protein levels but also amplifies its downstream transcriptional programs, including MYC, E2F, and cell cycle checkpoints, which are central to tumor proliferation.[6, 41] By binding to the ERα ligand‐binding domain (LBD)—a region implicated in mitochondrial localization[29, 36]—ARL3 integrates ERα signaling with subcellular compartmentalization, creating a nexus for oncogenic and metabolic regulation.