In Drosophila, DCAF12 regulates apoptosis through ubiquitin ligase‐independent cleavage of Diap1.[40] In stark contrast, we uncovered a pro‐metastatic role for DCAF12 in human lung cancer, mediated through ubiquitin‐dependent regulation of the TRiC/CCT complex. Here, DIAPH1 is linked to lung carcinoma.