The following frequency of TP53 variants was observed: 10.3% (3/29) in CCAs, 4.3% (2/46) in SG and 0% (0/93) DG PAs, with significant difference between CCAs and DG corticotroph adenomas (p = 0.0124). This evidence concerns the gene TP53 and ACTH-producing pituitary gland adenoma.