HMGCS2 and inflammatory bowel disease: Underlining the translatability of findings to the human disease condition, a downregulation of the ketogenesis pathway, as expected by a drop in HMGCS2 expression, has been described for colonocytes of patients CD35 and in line, reduced levels of the ketone body β-hydroxybutyrate were observed in the colonic mucosa of patients with IBD, which correlated with IBD activity index.99