Yet, corroborating an inflammation-mediated over a genetic effect, we did not find any reduction in GLP-1+ (Figure 1H, I) in noninflamed IL-10-/- mice on C57BL/6 background or Rag2-/- mice reconstituted with regulatory CD4+ CD25+ T cells, thus not developing colitis. The gene discussed is GCG; the disease is colitis.